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Related Experiment Videos

[Aldosterone antagonists: new pharmacologic prospects]

W De Jong1, M Grima, M Barthelmebs

  • 1Institut de Pharmacologie, Faculté de Médecine, Strasbourg, France.

Therapie
|October 17, 1998
PubMed
Summary

Spironolactone and related drugs are reviewed, focusing on how new discoveries about corticosteroid receptors and 11 beta-hydroxysteroid dehydrogenase isoforms may lead to novel uses for aldosterone antagonists.

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Area of Science:

  • Endocrinology and Pharmacology
  • Molecular Biology
  • Biochemistry

Context:

  • Recent advances in understanding corticosteroid receptor structure.
  • Identification of distinct isoforms of 11 beta-hydroxysteroid dehydrogenase (11β-HSD).
  • The role of 11β-HSD type 2 in selective mineralocorticoid receptor activation.

Purpose:

  • To review the pharmacology of spironolactone and analogues.
  • To integrate new findings on corticosteroid receptors and 11β-HSD isoforms.
  • To explore potential new clinical applications for aldosterone antagonists.

Summary:

  • The review discusses spironolactone's pharmacology in context of new data on corticosteroid receptors.
  • Highlights the tissue-specific function of 11β-HSD type 2 in mediating aldosterone receptor specificity.

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  • Identifies key tissues expressing 11β-HSD type 2, including kidney, colon, and hypothalamus.

    • Impact:

    • Potential for novel therapeutic strategies targeting the mineralocorticoid receptor.
    • New uses for aldosterone antagonists in conditions like myocardial fibrosis.
    • Improved understanding of hypertension linked to mineralocorticoid receptor dysfunction and glucocorticoid excess protection deficiencies.