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Updated: Jul 24, 2026

Assessment and Evaluation of the High Risk Neonate: The NICU Network Neurobehavioral Scale
Published on: August 25, 2014
Newborn predictors of infant irritability
M R Keefe1, A Froese-Fretz, A M Kotzer
1College of Nursing, Medical University of South Carolina, Charleston 29425, USA.
Newborn infant motor activity and responsiveness to stimuli in early life may predict later infant irritability, or colic. Nurse ratings of crying did not predict colic development, suggesting a focus on infant behaviors is key.
Area of Science:
- Neonatal behavioral research
- Infant development studies
- Pediatric health
Background:
- Infant irritability, commonly known as colic, affects a significant number of newborns.
- Predicting and understanding the origins of infant colic is crucial for parental support and infant well-being.
Purpose of the Study:
- To identify specific newborn infant behaviors observable in the first few days of life that may predict the later development of infant irritability (colic).
Main Methods:
- Prospective, correlational study design involving 60 healthy, full-term infants.
- Data collection included nurse-reported crying and Neonatal Behavioral Assessment Scale (NBAS) at 1-4 days of age, and parent-reported irritability via the Fussiness Rating Scale at 1 month.
- Exclusion criteria included congenital anomalies, illness, or high-risk factors.
Main Results:
- Two NBAS components predicted infant irritability at 1 month: motor activity and the infant's attentiveness to stimuli.
- Infants later classified as irritable exhibited higher motor activity and greater attentiveness to stimuli in the neonatal period.
- Nurse ratings of newborn crying were not significantly related to the development of colic.
Conclusions:
- Infant motor activity and sensitivity to stimuli in the early days of life may be predisposed factors for developing infant irritability.
- Further research is needed to explore the interplay between these infant characteristics and their environmental and interactional contexts.
- Neonatal behavioral assessments may offer more predictive value for colic than nurse observations of crying.
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