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Early feeding, antenatal glucocorticoids, and human milk decrease intestinal permeability in preterm infants

R J Shulman1, R J Schanler, C Lau

  • 1USDA/ARS Children's Nutrition Research Center, Department of Pediatrics, Baylor College of Medicine, and Texas Children's Hospital, Houston 77030, USA.

Pediatric Research
|October 17, 1998
PubMed
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Early feeding and antenatal steroids improve intestinal permeability in preterm infants. Human milk also reduces permeability, highlighting key factors for infant gut health and development.

Area of Science:

  • Neonatal physiology
  • Gastroenterology
  • Pediatric nutrition

Background:

  • Intestinal permeability is a critical factor in preterm infant health.
  • Factors influencing gut barrier function in neonates require further investigation.

Purpose of the Study:

  • To investigate the impact of age, feeding regimen, and antenatal glucocorticoids on intestinal permeability in preterm infants.
  • To compare the effects of different feeding strategies and diets on gut barrier function.

Main Methods:

  • A randomized controlled trial involving 132 preterm infants.
  • Stratification by gestational age and diet (mother's own milk vs. preterm formula).
  • Assessment of intestinal permeability using the lactulose/mannitol ratio at 10, 28, and 50 days of age.

Related Experiment Videos

Main Results:

  • Intestinal permeability significantly changed with infant age (p = 0.003).
  • Early feeding strategies reduced permeability at 10 days (p = 0.01).
  • Antenatal steroid administration (p = 0.017) and human milk feeding (p = 0.02) decreased permeability at 28 days.

Conclusions:

  • Age, early feeding initiation, antenatal glucocorticoids, and human milk consumption are significant modulators of intestinal permeability in preterm infants.
  • Feeding regimens and diet play a crucial role in establishing gut barrier integrity during early infancy.
  • Continuous versus bolus feeding did not demonstrate a significant effect on intestinal permeability.