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Related Experiment Videos

Target height as predicted by parental heights in a population-based study

Z C Luo1, K Albertsson-Wikland, J Karlberg

  • 1Department of Pediatrics, University of Hong Kong, Pokfulam, SAR.

Pediatric Research
|October 17, 1998
PubMed
Summary

A new linear function estimates children's target height more accurately than the Tanner method, especially for those with short parents. This improved prediction aids in evaluating growth-promoting therapies.

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Area of Science:

  • Pediatrics
  • Genetics
  • Anthropometry

Background:

  • The Tanner method (1970) is standard for estimating target height to assess growth therapies.
  • Existing methods lack clarity on whether target height equations should differ based on parental stature.

Purpose of the Study:

  • To evaluate predicted target height values using parental heights in a large population.
  • To compare a proposed linear function with the Tanner method for target height estimation.

Main Methods:

  • Analysis of a large population-based study (n=2402) examining predicted target height.
  • Development and application of a simple linear function: y = 45.99 + 0.78x (boys), y = 37.85+0.75x (girls).

Main Results:

  • The proposed linear model showed similar predictions for boys and girls in SD scores (SDS) and was unaffected by assortative mating.

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  • The new model may underestimate stature by ~2 cm for children with very short parents (midparental height <-2 SDS), whereas the Tanner method could err by 6 cm.
  • The model is recommended over the Tanner method for clinical evaluation, particularly for short children with short parents.

    • Conclusions:

    • A new linear function offers improved target height estimation compared to the Tanner method, especially for children with short parents.
    • Results support polygenic inheritance patterns for stature.
    • Further research is needed for a distinct function for children with very short parents.