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Naturally occurring and experimentally induced eastern encephalomyelitis in calves

A R Pursell, F E Mitchell, H R Seibold

    Journal of the American Veterinary Medical Association
    |November 15, 1976
    PubMed
    Summary

    Eastern encephalomyelitis virus was isolated from calves with neurological disease. The virus successfully reproduced the condition in a healthy calf, confirming its role in bovine encephalomyelitis.

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    Area of Science:

    • Veterinary Neurology
    • Virology
    • Pathology

    Background:

    • Eastern encephalomyelitis virus (EEV) is a known cause of neurological disease in various animal species.
    • Encephalomyelitis in calves can have multiple etiologies, necessitating specific etiological identification.

    Purpose of the Study:

    • To isolate and identify the causative agent of encephalomyelitis in two calves.
    • To experimentally reproduce the disease in a healthy calf to confirm the isolated virus's pathogenicity.

    Main Methods:

    • Viral isolation from brain tissue of affected calves.
    • Intracerebral inoculation of a healthy calf with the isolated virus.
    • Clinical and histopathological examination of the experimentally infected calf.

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    Main Results:

    • Eastern encephalomyelitis virus was successfully isolated from the brain of two encephalomyelitic calves.
    • The isolated EEV reproduced clinical signs and pathological lesions consistent with eastern encephalomyelitis in a experimentally infected calf.
    • Histopathological findings in the experimentally infected calf matched descriptions of EEV-induced disease in horses.

    Conclusions:

    • Eastern encephalomyelitis virus is an etiological agent of encephalomyelitis in calves.
    • The study confirms the pathogenicity of EEV in bovines, expanding its known host range.
    • This finding has implications for differential diagnosis and disease management in cattle.