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Updated: Jul 31, 2026
26:48
Induction and Clinical Scoring of Chronic-Relapsing Experimental Autoimmune Encephalomyelitis
Published on: July 4, 2007
Naturally occurring and experimentally induced eastern encephalomyelitis in calves
Journal of the American Veterinary Medical Association
|November 15, 1976
Summary
Eastern encephalomyelitis virus was isolated from calves with neurological disease. The virus successfully reproduced the condition in a healthy calf, confirming its role in bovine encephalomyelitis.
Area of Science:
- Veterinary Neurology
- Virology
- Pathology
Background:
- Eastern encephalomyelitis virus (EEV) is a known cause of neurological disease in various animal species.
- Encephalomyelitis in calves can have multiple etiologies, necessitating specific etiological identification.
Purpose of the Study:
- To isolate and identify the causative agent of encephalomyelitis in two calves.
- To experimentally reproduce the disease in a healthy calf to confirm the isolated virus's pathogenicity.
Main Methods:
- Viral isolation from brain tissue of affected calves.
- Intracerebral inoculation of a healthy calf with the isolated virus.
- Clinical and histopathological examination of the experimentally infected calf.
Main Results:
- Eastern encephalomyelitis virus was successfully isolated from the brain of two encephalomyelitic calves.
- The isolated EEV reproduced clinical signs and pathological lesions consistent with eastern encephalomyelitis in a experimentally infected calf.
- Histopathological findings in the experimentally infected calf matched descriptions of EEV-induced disease in horses.
Conclusions:
- Eastern encephalomyelitis virus is an etiological agent of encephalomyelitis in calves.
- The study confirms the pathogenicity of EEV in bovines, expanding its known host range.
- This finding has implications for differential diagnosis and disease management in cattle.
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