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Prognostic factors in gastric cancer evaluated by using Cox regression model
G Ghiandoni1, M B Rocchi, P Signoretti
1Istituto di Biomatematica, Università degli Studi, Urbino.
Minerva Chirurgica
|October 17, 1998
Summary
Gastric cancer surgery prognosis depends on lymph node status, tumor extension, and patient age. Early diagnosis and patient age are key short-term prognostic factors.
Area of Science:
- Oncology
- Surgical Gastroenterology
Background:
- Gastric cancer necessitates understanding prognostic factors for effective treatment planning.
- Short-term outcomes are crucial for patient management post-surgery.
Purpose of the Study:
- To determine the most significant short-term prognostic variables in patients undergoing gastric cancer surgery.
- To identify predictors influencing immediate outcomes after gastric cancer removal.
Main Methods:
- Retrospective survival analysis using the Cox regression model.
- Analysis of 129 consecutive patients undergoing total or subtotal gastrectomy.
- Follow-up period ranged from 18 to 90 months.
Main Results:
- Lymph node involvement (N) was a highly significant prognostic factor (p < 0.0001).
- Intraparietal tumor extension (T) significantly impacted prognosis (p < 0.001).
- Patient age was also identified as a significant prognostic factor (p < 0.05).
Conclusions:
- Short-term prognosis in gastric cancer is strongly influenced by the stage of diagnosis.
- Patient age is a critical factor affecting short-term outcomes after surgery.
- These factors aid in predicting recovery and survival post-gastrectomy.