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[Deep venous thrombosis in an adult with varicella]
D Barcat1, J Constans, M Seigneur
1Service de médecine interne et pathologie vasculaire, Hôpital Saint-André, Bordeaux, France.
Introduction:
Some viral infections are associated with deep venous thrombosis. We report a case of deep venous thrombosis in an adult with varicella. He had neither known predisposing factors for thrombosis nor thrombophilia.
Exegesis:
Transient significant level of antiphospholipid antibodies and lupus circulating anticoagulant were observed. There was no evidence of thrombophilia. Deep venous thrombosis has been mostly associated with varicella in children. A transient protein S deficiency was present in almost all cases, though it was sometimes related to an anti-protein S antibody. This association is exceptional in adults. Some viruses such as herpesvirus and HIV are responsible for endothelium dysfunction, but this is still unclear in the case of varicella-zoster virus.
Conclusion:
In our observation, endothelium activation or antiphospholipid antibodies might be responsible for thrombosis.