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Related Experiment Videos

The effect of timolol drops on respiratory function

S A Sadiq1, K Fielding, S A Vernon

  • 1Department of Ophthalmology, Queen's Medical Centre, Nottingham, UK.

Eye (London, England)
|October 17, 1998
PubMed
Summary
This summary is machine-generated.

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Topical timolol may cause mild bronchial obstruction, indicated by a decrease in forced expiratory volume (FEV), even in patients without prior respiratory issues. This effect, though statistically significant, was not clinically significant in the study.

Area of Science:

  • Ophthalmology
  • Pharmacology
  • Pulmonary Medicine

Background:

  • Topical timolol is frequently used for glaucoma treatment.
  • Concerns exist regarding potential adverse respiratory effects, particularly in elderly patients.
  • The impact of timolol on lung function in individuals without pre-existing respiratory disease requires further investigation.

Purpose of the Study:

  • To evaluate the effects of topical timolol on lung function.
  • To assess respiratory changes in patients without prior respiratory conditions.
  • To determine if timolol causes alterations in lung function parameters.

Main Methods:

  • A placebo-controlled, randomized, double-masked, cross-over study.
  • Involved 20 ocular hypertensive patients.

Related Experiment Videos

  • Measured lung function parameters (PFR, FEV, VC, FEV/VC ratio) after topical or systemic administration of timolol or placebo.

    • Main Results:

    • A statistically significant fall in forced expiratory volume (FEV) and FEV/VC ratio was observed two hours post-timolol administration.
    • No significant changes were noted in peak expiratory flow rate (PFR) or vital capacity (VC).
    • The reduction in FEV was more pronounced following topical application compared to systemic administration.

    Conclusions:

    • Topical timolol demonstrated a tendency towards mild bronchial obstruction in the study group.
    • The observed bronchial obstruction was not considered clinically significant.
    • These findings suggest careful monitoring of respiratory function may be warranted in susceptible individuals.