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Related Experiment Videos

Wegener's granulomatosis. First case report in Bahrain

A Jamal1, R A Ebrahim, N Tammam

  • 1Department of Otolaryngology, Salmaniya Medical Complex, Bahrain.

The Journal of Laryngology and Otology
|October 17, 1998
PubMed
Summary

Wegener's granulomatosis, once fatal, is now treatable. This report details the first diagnosed case in Bahrain, presenting with epistaxis and confirmed via cANCA testing, showing positive treatment outcomes.

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Epidemiology and infection·2020

Area of Science:

  • Rheumatology
  • Nephrology
  • Otolaryngology

Background:

  • Wegener's granulomatosis (WG) is a rare systemic vasculitis.
  • Historically associated with high mortality, modern treatments have improved outcomes.
  • Incidence estimates in Europe and America range from 1:250,000.

Observation:

  • This case report documents the first diagnosis of WG in Bahrain, a nation with an estimated population of 586,110 in 1997.
  • The patient presented with epistaxis and was diagnosed based on clinical presentation, elevated ESR, histopathological findings, and positive cANCA.
  • The diagnosis was confirmed using clinical, operative, histopathological, radiological, and immunological (positive cANCA) assessments.

Findings:

  • The patient received standard treatment comprising cytotoxic agents and corticosteroids.

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  • Clinical and laboratory parameters showed progressive improvement during follow-up.
  • Successful management of WG in a previously unreported region highlights diagnostic and therapeutic advancements.

    • Implications:

    • This case expands the known geographical distribution of WG.
    • Early diagnosis and appropriate treatment are crucial for favorable outcomes in WG.
    • Further epidemiological studies in Bahrain and surrounding regions are warranted.