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Long-term metabolic effects in patients with urinary diversion
1Department of Urology, University of Mainz, School of Medicine, Germany.
World Journal of Urology
|October 17, 1998
Summary
Genitourinary reconstruction using intestinal segments may lower vitamin B12 in adults long-term. Bone mineral density remained normal, but regular vitamin B12 monitoring is advised after four years post-surgery.
Area of Science:
- Urology
- Gastroenterology
- Endocrinology
Background:
- Intestinal segments used in genitourinary reconstruction can impact vitamin metabolism.
- Long-term effects on bone mineral content require investigation.
Purpose of the Study:
- To assess vitamin levels and bone mineral density in patients after intestinal segment-based genitourinary reconstruction.
- To identify potential long-term metabolic and skeletal complications.
Main Methods:
- Serum levels of vitamins A, B1, B2, B6, B12, D, E, folic acid, bile acid, and ammonia were measured in 137 patients.
- Red blood cell count and intracorpuscular vitamin B12/folic acid levels were assessed.
- Bone mineral density was evaluated using dual-photon absorptiometry in 25 patients.
Main Results:
- All measured vitamin and red blood cell levels were within normal ranges for all patients.
- Adults showed a significant decrease in serum vitamin B12 levels after 4 years post-surgery.
- Bone mineral density was normal in all assessed patients, regardless of urinary diversion type.
Conclusions:
- Adults undergoing genitourinary reconstruction with intestinal segments may experience a decline in vitamin B12 levels over time.
- Routine monitoring of vitamin B12 levels is recommended 4 years after urinary diversion.
- No adverse effects on bone mineral content were observed in the long-term follow-up.