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Necrotizing toxoplasmic encephalitis in a child with the X-linked hyper-IgM syndrome
I Tsuge1, H Matsuoka, A Nakagawa
1Department of Paediatrics, Nagoya University School of Medicine, Japan.
European Journal of Pediatrics
|October 17, 1998
Abstract
Unlabelled:
We report on a 9-year-old boy with the hyper-IgM syndrome who presented with rapid impairment of consciousness. The brain CT scan showed multiple round lucencies, and the brain histology revealed necrotizing toxoplasmic encephalitis. This patient, whose CD40/CD40 ligand system was impaired, indicates the importance of this system for defence against toxoplasmic infection.
Conclusion:
Although disseminated toxoplasmosis is a rare complication of the hyper-IgM syndrome, it must be included in the differential diagnosis of infections.