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Benzodiazepine binding site-interactive flavones from Scutellaria baicalensis root
1Department of Pharmacology, National Yang-Ming University, Taipei, Taiwan, Republic of China.
Planta Medica
|October 17, 1998
Abstract:
A benzodiazepine binding assay directed separation led to the identification of 3 flavones baicalein (1), oroxylin A (2), and skullcapflavone II (3) from the water extract of Scutellaria baicalensis root. Compounds 1, 2, and 3 interacted with the benzodiazepine binding site of GABAA receptors with a Ki value of 13.1, 14.6 and 0.36 micromol/L, respectively.