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Related Experiment Videos

The corrected TIMI frame count. The new gold standard?

J K French1, C J Ellis, H D White

  • 1Cardiology Department, Green Lane Hospital, Auckland, New Zealand.

Australian and New Zealand Journal of Medicine
|October 20, 1998
PubMed
Summary

The corrected TIMI frame count (CTFC) offers a more reproducible measure of infarct artery blood flow after myocardial infarction (MI). Abnormal CTFCs are common and predict reocclusion, suggesting potential advantages over traditional TIMI flow grades.

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Area of Science:

  • Cardiovascular Medicine
  • Interventional Cardiology
  • Biomedical Engineering

Background:

  • Thrombolysis in Myocardial Infarction (TIMI) flow grades are standard for assessing infarct-artery reperfusion efficacy.
  • Reproducibility issues with TIMI flow grades have emerged with core angiographic laboratories.
  • The corrected TIMI frame count (CTFC) was developed to improve reproducibility in quantifying infarct artery blood flow post-myocardial infarction (MI).

Purpose of the Study:

  • To evaluate the utility of the corrected TIMI frame count (CTFC) in assessing infarct-artery blood flow.
  • To investigate the relationship between CTFC and left ventricular function (LVF).
  • To determine if CTFC predicts reocclusion after MI.

Main Methods:

  • Utilized CTFC in two studies examining infarct-artery blood flow post-MI.

Related Experiment Videos

  • In the HERO 1 study, CTFC was measured after thrombolytic therapy and anticoagulation.
  • Infarct-artery flow was assessed using CTFC at four weeks and one year post-MI.

    • Main Results:

    • Only 27% of patients in the HERO 1 study had a normal CTFC (< or = 27) at 90-120 minutes.
    • Prolonged CTFC (> 27) correlated with more abnormal LVF (mean chord score -2.51 vs -2.06, p=0.02).
    • At four weeks post-MI, 43% of patients had normal CTFC; prolonged CTFC predicted increased one-year reocclusion (p=0.001).

    Conclusions:

    • Corrected TIMI frame counts (CTFCs) are frequently abnormal in patent infarct-related arteries.
    • Abnormal CTFCs are predictive of reocclusion after myocardial infarction.
    • Prospective trials are needed to determine if CTFC predicts late clinical outcomes better than TIMI flow grade.