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Endogenous estrogen modulates phenothiazine stimulated prolactin secretion
The Journal of Clinical Endocrinology and Metabolism
|October 1, 1976
Summary
Endogenous estrogen influences prolactin secretion in women. Higher estrogen levels during the menstrual cycle correlate with a greater prolactin response to phenothiazine stimulation, suggesting a regulatory role.
Area of Science:
- Endocrinology
- Reproductive Biology
- Neuroendocrinology
Background:
- The precise role of endogenous estrogen in regulating serum prolactin concentration in humans remains debated.
- Understanding this interaction is crucial for comprehending reproductive hormone dynamics.
Purpose of the Study:
- To investigate the effect of endogenous estrogen fluctuations on prolactin secretion regulation.
- To compare prolactin secretion during different phases of the menstrual cycle with varying estrogen levels.
Main Methods:
- Phenothiazine-stimulated prolactin secretion was measured in 12 women during the early follicular phase (low estrogen) and late follicular phase (high estrogen).
- Serum estrogen (E1 + E2) and prolactin concentrations were quantified at baseline and after stimulation.
Main Results:
- Basal serum prolactin levels were comparable between the early and late follicular phases.
- The integrated prolactin response to phenothiazine was significantly elevated during the late follicular phase (higher estrogen) compared to the early follicular phase (lower estrogen).
Conclusions:
- Endogenous estrogen appears to play a significant role in modulating serum prolactin concentrations in women.
- These findings contribute to understanding the neuroendocrine regulation of prolactin during the menstrual cycle.