Fixed drug eruption induced by indapamide. Cross-reactivity with sulfonamides
M De Barrio1, P Tornero, J M Zubeldia
1Section of Allergology, Hospital General Universitario Gregorio Marañón, Madrid, Spain.
Abstract:
Indapamide is a nontiazidic sulfonamide diuretic which has not been previously reported as a cause of fixed drug eruption. We describe a patient who experienced several episodes of fixed drug eruption during treatment with indapamide. The diagnosis was confirmed by positive controlled oral challenge test. The possible existence of cross-reactivity with other sulfonamide derivatives was investigated by controlled oral challenge test with sulfamethoxazole, sulfadiazine and furosemide, with the tests with sulfamethoxazole and sulfadiazine resulting positive.
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