Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Remyelination: cellular and gene therapy

L L Billinghurst1, R M Taylor, E Y Snyder

  • 1Department of Neurology, Harvard Medical School, Children's Hospital, Boston, MA 02115, USA.

Seminars in Pediatric Neurology
|October 20, 1998
PubMed
Summary

Neural stem cells offer promising therapeutic potential for pediatric neurological diseases involving myelin dysfunction. Their ability to replace cells and deliver genes may enable effective myelin repair across various conditions.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Impact of a cancer diagnosis on educational, employment, health-related quality of life, and social outcomes among young adults: A matched cohort study of 401 cancer survivors aged 15-24 in England.

Social science & medicine (1982)·2025
Same author

Permanent Indian ink tattoos for breast cancer radiotherapy: A United Kingdom study of the emotional impact on patients following radiotherapy.

Radiography (London, England : 1995)·2024
Same author

Systematic review of the use of translated patient-reported outcome measures in cancer trials.

Trials·2021
Same author

Retrospective study on the occurrence of canine lymphoma and associated breed risks in a population of dogs in NSW (2001-2009).

Australian veterinary journal·2017
Same author

Associations between neurologic dysfunction and lesions in canine fucosidosis.

Genes, brain, and behavior·2015
Same author

Micro-elastometry on whole blood clots using actuated surface-attached posts (ASAPs).

Lab on a chip·2015

Area of Science:

  • Neuroscience
  • Cell Biology
  • Regenerative Medicine

Background:

  • Dysfunctional myelination and oligodendroglial abnormalities are implicated in numerous pediatric neurological diseases.
  • Recent advancements in glial cell biology suggest remyelination strategies are becoming increasingly feasible.
  • Myelin repair evidence is growing in experimental models of dysmyelinating and demyelinating conditions.

Purpose of the Study:

  • To explore the potential of neural stem cells (NSCs) as a multifaceted therapeutic approach for pediatric myelin disorders.
  • To evaluate the suitability of NSCs for both cell replacement and gene delivery in the central nervous system.
  • To address the complex repair needs of myelin dysfunction across a broad spectrum of pediatric neurological diseases.

Main Methods:

Related Experiment Videos

  • Review of recent advances in glial cell biology and myelin repair strategies.
  • Analysis of experimental models for dysmyelination and demyelination.
  • Evaluation of therapeutic approaches including cell replacement (oligodendrocytes, precursors, NSCs) and gene therapy (genetic vectors).

Main Results:

  • Evidence supports the feasibility of remyelination strategies in experimental models.
  • Multiple repair strategies may be necessary for myelin disorders, combining cell replacement and gene product supplementation.
  • Multipotent neural stem cells demonstrate suitability for both gene transfer and cell replacement in diverse pathological conditions.

Conclusions:

  • Neural stem cells possess inherent biological properties ideal for addressing myelin dysfunction in pediatric neurological diseases.
  • NSCs offer a promising platform for cell replacement and gene delivery, potentially treating multiple regions of the central nervous system.
  • The multifaceted therapeutic capabilities of NSCs align with the complex demands of pediatric myelin disorders, suggesting their significant clinical potential.