Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Impediments to wound healing

W K Stadelmann1, A G Digenis, G R Tobin

  • 1Division of Plastic and Reconstructive Surgery, University of Louisville, Kentucky 40292, USA.

American Journal of Surgery
|October 20, 1998
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

The history of human composite tissue allotransplantation.

Transplantation proceedings·2009
Same author

Ethical considerations in the early composite tissue allograft experience: a review of the Louisville Ethics Program.

Transplantation proceedings·2005
Same author

The use of selective lymphadenectomy in malignant blue naevus of the scalp.

British journal of plastic surgery·2003
Same author

Dynamic rectus abdominis muscle flap for intestinal stomal continence: a systematic approach.

Microsurgery·2001
Same author

Analysis of chronic morphologic changes of small bowel in electrically stimulated canine island-flap rectus abdominis muscle stomal sphincters.

Diseases of the colon and rectum·2001
Same author

Hand transplantation follow-up.

Lancet (London, England)·2001

Chronic wound healing requires addressing inhibitory factors like hypoxia and infection. While growth factor therapy can help, a supportive physiologic environment is crucial for effective tissue repair and regeneration.

Area of Science:

  • Wound healing research
  • Regenerative medicine

Background:

  • Chronic wounds often fail to heal due to various inhibitory factors.
  • Recombinant growth factor therapy is explored as an adjunct treatment.

Purpose of the Study:

  • To review the key factors impeding chronic wound healing.
  • To emphasize the necessity of a conducive physiologic environment for effective treatment.

Main Methods:

  • Literature review of common chronic wound impediments.
  • Analysis of the role of growth factors in wound repair.

Main Results:

  • Key impediments include hypoxia, infection, necrotic tissue, nutritional deficiencies, and metabolic disorders like diabetes.
  • The efficacy of growth factor therapy is contingent upon addressing these underlying issues.

Related Experiment Videos

Conclusions:

  • Successful chronic wound management necessitates identifying and correcting factors that inhibit healing.
  • A physiologic environment supporting tissue repair is paramount, regardless of therapeutic interventions.