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Transtympanic gentamicin for Meniere's syndrome

S G Harner1, J L Kasperbauer, G W Facer

  • 1Department of Otolaryngology, Mayo Clinic, Rochester, Minnesota 55905, USA. sharner@mayo.edu

The Laryngoscope
|October 20, 1998
PubMed
Summary

Transtympanic gentamicin effectively treats unilateral Meniere's syndrome, reducing vertigo while preserving hearing. This partial chemical labyrinthectomy offers a viable treatment option for patients unresponsive to medical therapies.

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Area of Science:

  • Otolaryngology
  • Neurology

Background:

  • Meniere's syndrome is a debilitating inner ear disorder characterized by vertigo, hearing loss, and tinnitus.
  • Transtympanic gentamicin offers a less invasive alternative to surgical labyrinthectomy for Meniere's disease management.

Purpose of the Study:

  • To evaluate the efficacy and safety of transtympanic gentamicin injections for treating unilateral Meniere's syndrome.
  • To assess the impact of gentamicin on vertigo symptoms and cochlear function.

Main Methods:

  • A prospective study involving 43 patients with unilateral Meniere's syndrome who failed medical therapy.
  • Patients received one or more transtympanic gentamicin injections, with audiometric and electronystagmography data collected pre- and post-treatment.
  • Follow-up data were collected using established clinical guidelines.

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Main Results:

  • Significant reduction in vertigo symptoms (function level decreased from 3-5 to 1-2) in most patients.
  • Preservation of cochlear function with no cases of deafness reported.
  • Mild, transient ataxia or dysequilibrium observed in some patients post-injection.

Conclusions:

  • Transtympanic gentamicin is an effective treatment for unilateral Meniere's syndrome, particularly for patients refractory to medical management.
  • The procedure demonstrates a favorable safety profile with minimal impact on hearing.