Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Integral rein control in physiology

P T Saunders1, J H Koeslag, J A Wessels

  • 1Department of Mathematics, King's College, Strand, London, WC2R 2LS, U.K.

Journal of Theoretical Biology
|October 21, 1998
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Immune cell and transcriptomic analysis of the human decidua in term and preterm parturition.

Molecular human reproduction·2017
Same author

MUTATIONS DO NOT ACCUMULATE IN ASEXUAL ISOLATES CAPABLE OF GROWTH AND EXTINCTION-MULLER'S RATCHET RE-EXAMINED.

Evolution; international journal of organic evolution·2017
Same author

Effect of genetic polymorphisms in genes encoding GST isoenzymes on BU pharmacokinetics in adult patients undergoing hematopoietic SCT.

Bone marrow transplantation·2011
Same author

Cellular injury in ischaemia.

Cardiovascular journal of South Africa : official journal for Southern Africa Cardiac Society [and] South African Society of Cardiac Practitioners·2004
Same author

Relationship between expression of sex steroid receptors and structure of the seminal vesicles after neonatal treatment of rats with potent or weak estrogens.

Environmental health perspectives·2001
Same author

Comparison of androgen receptor and oestrogen receptor beta immunoexpression in the testes of the common marmoset (Callithrix jacchus) from birth to adulthood: low androgen receptor immunoexpression in Sertoli cells during the neonatal increase in testosterone concentrations.

Reproduction (Cambridge, England)·2001
Same journal

The male-biased sex ratio in humans and its role in the transition from promiscuity to pair bonding.

Journal of theoretical biology·2026
Same journal

Quantifying the counter-intuitive effects of vaccination by coupling the transmission dynamics of COVID-19 and the evolution of human behaviors.

Journal of theoretical biology·2026
Same journal

An integrative model of FGF2-induced signaling and muscle cell proliferation.

Journal of theoretical biology·2026
Same journal

A hybrid reaction-diffusion and mechanical stimulus model for mandibular bone remodeling under chewing and vibratory loading.

Journal of theoretical biology·2026
Same journal

Integrated tick management strategies in fragmented peridomestic environments.

Journal of theoretical biology·2026
Same journal

Joint likelihood-free inference of the number of selected single nucleotide polymorphisms and their selection coefficients in an evolving population.

Journal of theoretical biology·2026
See all related articles

Blood glucose is regulated by integral rein control, balancing insulin and glucagon. This model explains stable blood glucose levels and shifts in set point for diabetes mellitus patients.

Area of Science:

  • Endocrinology
  • Systems Biology
  • Physiology

Background:

  • Blood glucose homeostasis is crucial for metabolic health.
  • Existing models of glucose regulation have limitations in explaining certain diabetic conditions.

Purpose of the Study:

  • To propose a novel control principle, integral rein control, for blood glucose regulation.
  • To explain the stability and set-point dynamics of blood glucose control.
  • To elucidate the physiological basis for differences in Type I and Type II diabetes mellitus.

Main Methods:

  • Development of a theoretical model based on integral control principles.
  • Mathematical analysis of hormone production rates and their dynamic interplay.
  • Application of the model to explain clinical observations in diabetes.

Related Experiment Videos

Main Results:

  • Integral rein control utilizes both insulin and glucagon, balancing their production for stable glucose levels.
  • The model demonstrates zero steady-state error, maintaining near-constant glucose despite varying demands.
  • The model predicts a shifted set point in insulin deficiency, explaining hyperglycemia in untreated Type I diabetes.

Conclusions:

  • Integral rein control provides a unified framework for understanding blood glucose regulation.
  • The model successfully explains the hyperglycemia in Type I diabetes and the relative ease of treatment in Type II diabetes.
  • The dynamic interplay between insulin and glucagon production rates is key to glucose set-point determination.