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Propylene glycol toxicosis in a mare
S McClanahan1, J Hunter, M Murphy
1Department of Clinical and Population Sciences, University of Minnesota, College of Veterinary Medicine, St Paul 55108, USA.
Veterinary and Human Toxicology
|October 21, 1998
Summary
Propylene glycol, used in veterinary medicine, can cause severe toxicosis in horses if accidentally overdosed. Prompt medical intervention is crucial for successful treatment and recovery from this condition.
Area of Science:
- Veterinary Medicine
- Toxicology
- Equine Health
Background:
- Propylene glycol is a common veterinary treatment for bovine ketosis.
- Mineral oil is frequently used for equine impactions.
Observation:
- Accidental administration of high doses (6.0 ml/kg) of propylene glycol in horses leads to significant clinical signs.
- Observed effects include severe depression, ataxia, and malodorous breath and feces.
Findings:
- High-dose propylene glycol administration in horses results in a distinct toxicosis syndrome.
- The toxic effects are characterized by neurological and gastrointestinal disturbances.
Implications:
- Understanding propylene glycol dosage is critical to prevent accidental equine toxicosis.
- Prompt and appropriate medical therapy is effective in treating propylene glycol toxicosis in horses.