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[Diffuse sclerosing papillary thyroid carcinoma. Report of two cases]
P Trincado1, J M López, E Oestreicher
1Departamento de Endocrinología, Escuela de Medicina, Pontificia Universidad Católica de Chile, Santiago, Chile.
Revista Medica De Chile
|October 21, 1998
Summary
Diffuse sclerosing papillary thyroid carcinoma often presents as a goiter with an irregular surface, potentially linked to thyroid dysfunction, especially in young women. Early suspicion and fine needle aspiration are key for diagnosis.
Area of Science:
- Endocrinology
- Oncology
- Pathology
Background:
- Diffuse sclerosing papillary thyroid carcinoma is a distinct subtype of papillary thyroid carcinoma.
- It often presents differently from classical papillary thyroid carcinoma, appearing as a diffuse goiter.
Observation:
- The condition is associated with thyroid dysfunction, including hypothyroidism and hyperthyroidism.
- It is particularly noted in younger women.
- Two cases are presented: one 41-year-old with normal thyroid function and a 23-year-old with hyperthyroidism.
Findings:
- Diffuse sclerosing papillary thyroid carcinoma should be suspected in patients with rapidly enlarging goiters with irregular surfaces or diffuse microcalcifications.
- The presence of hypo or hyperthyroidism increases suspicion.
Implications:
- Prompt diagnosis is crucial for effective management of this thyroid malignancy.
- Fine needle aspiration is highlighted as a valuable diagnostic tool for this condition.