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Contrast media with and without calcium for cardioangiography in children
Insights
Adding calcium to contrast media for pediatric cardioangiography showed no significant myocardial, fluid, or electrolyte effects. This study evaluated contrast agents in children and adolescents undergoing cardiac catheterization.
Area of Science:
- Cardiology
- Pediatric Cardiology
- Radiology
Background:
- Myocardial toxicity is a concern with contrast media during cardiac procedures.
- Calcium ions have been proposed to mitigate these adverse effects.
Purpose of the Study:
- To evaluate the potential beneficial effects of calcium-added contrast media on myocardial toxicity.
- To assess the impact of calcium in contrast agents on fluid and electrolyte balance in pediatric patients.
Main Methods:
- A comparative study involving 93 cardiac catheterizations with cardioangiography in 50 children and adolescents.
- Two contrast media with identical iodine content (370 mg/ml) and physical properties were used: Isopawue-370 (with calcium) and Renografin-76 (without calcium).
Main Results:
- Selective injection of contrast media into cardiac chambers or great vessels was performed.
- No significant alterations in myocardial, fluid, or electrolyte effects were observed with the addition of calcium.
Conclusions:
- The addition of calcium to contrast media does not appear to alter myocardial, fluid, or electrolyte effects in pediatric cardioangiography.
- Calcium supplementation in contrast agents is not beneficial for reducing toxicity in this patient population.
Abstract:
The possible beneficial effects of added calcium ions to contrast media to diminish myocardial toxicity was evaluated in 93 cardiac catheterizations with cardioangiography, performed in 50 children and adolescents. Two contrast media with equal iodine content (370 mg/ml) and similar physical properties were used: Isopawue-370, containing 0.34 mg calcium/ml, and Renografin-76, not containing calcium. It is concluded that addition of calcium to contrast media for cardioangiography in children and adolescents does not alter their myocardial, fluid or electrolyte effects when injected selectively into the cardiac chambers or great vessels.