NIRS: dose dependency of local changes of cerebral HbO2 and Hb with pCO2 in parietal cortex

Regional cerebral oxygenated hemoglobin and total hemoglobin increased systematically with increasing depth of hypercapnia, but the concentration of deoxygenated hemoglobin remained relatively constant. Relative mean changes of oxygenated and total hemoglobin increased nearly linearly, corresponding to the characteristic increase of the cerebral vascular dilation with increasing depth of hypercapnia.