Inhibitors of gamma-aminobutyric acid transport as experimental tools and therapeutic agents

The orthosteric GABAA receptor ligand Thio-4-PIOL displays distinctly different functional properties at synaptic and extrasynaptic receptors.

British journal of pharmacology·2013

Lack of a high affinity uptake system for the GABA agonists THIP and isoguvacine in neurons and astrocytes cultured from mouse brain.

Neurochemistry international·2010

Characterization of the uptake of GABA, nipecotic acid and cis-4-OH-nipecotic acid in cultured neurons and astrocytes.

Neurochemistry international·2010

Multi-component analysis of marine lipids in fish gonads with emphasis on phospholipids using high resolution NMR spectroscopy.

Chemistry and physics of lipids·2006

Modification of the philanthotoxin-343 polyamine moiety results in different structure-activity profiles at muscle nicotinic ACh, NMDA and AMPA receptors.

Neuropharmacology·2003

Recent advances in the medicinal chemistry of polyamine toxins.

Mini reviews in medicinal chemistry·2002

Comparative methods for recombinant production and characterization of 1-deoxy-D-xylulose-5-phosphate synthase from bacterial and apicomplexan sources.

Methods in enzymology·2026

Current methods and applications in the study of 1-Deoxy-D-xylulose 5-phosphate synthase (DXPS).

Methods in enzymology·2026

Thiamine pyrophosphate-dependent enzymes in Toxoplasma gondii and functional significance of an apicoplast-localized pyruvate dehydrogenase.

Methods in enzymology·2026

Biochemical and cryo-EM studies of the pyruvate dehydrogenase complex from native cell extracts.

Methods in enzymology·2026

Synthesis of phosphonate and phosphinate analogs of 2-oxo acids for site-specific inhibition of thiamine-diphosphate-dependent dehydrogenases of 2-oxo acids in vivo.

Methods in enzymology·2026

Use of dihydroxyacetone synthase for the assimilation of methanol in E. coli.

Methods in enzymology·2026

Apoptosis-inducing potential of the hexane fraction of Cassia fistula L. against MCF-7 cells via apoptosis signaling pathways.

Biochemistry and biophysics reports·2026

A novel 1,3-diazetidine-2-thione derivative with antibacterial and immunomodulatory activity against Proteus mirabilis: in vitro, in vivo, ADMET, docking, and molecular dynamics evaluation.

In silico pharmacology·2026

DancE: A DNA-Activated Bacterial cGAS-like Enzyme in Antiphage Immune Defense.

bioRxiv : the preprint server for biology·2026

Reversible, Orally Bioavailable Small-Molecule Inhibitors Occupy the Substrate Tunnel of the Thioesterase Domain of Fatty Acid Synthase.

bioRxiv : the preprint server for biology·2026

Peptides derived from TsAP-2 exhibit potential antifungal activity against Candida species and promote non-infected wound healing both in vitro and in vivo.

Biochimie·2026

Dysoverines G-K from the rhizome of Dysosma tonkinense and their cytotoxic activity.

Fitoterapia·2026

Related Experiment Videos

Inhibitors of gamma-aminobutyric acid transport as experimental tools and therapeutic agents

Related Concept Videos

The orthosteric GABAA receptor ligand Thio-4-PIOL displays distinctly different functional properties at synaptic and extrasynaptic receptors.

Lack of a high affinity uptake system for the GABA agonists THIP and isoguvacine in neurons and astrocytes cultured from mouse brain.

Characterization of the uptake of GABA, nipecotic acid and cis-4-OH-nipecotic acid in cultured neurons and astrocytes.

Multi-component analysis of marine lipids in fish gonads with emphasis on phospholipids using high resolution NMR spectroscopy.

Modification of the philanthotoxin-343 polyamine moiety results in different structure-activity profiles at muscle nicotinic ACh, NMDA and AMPA receptors.

Recent advances in the medicinal chemistry of polyamine toxins.

Comparative methods for recombinant production and characterization of 1-deoxy-D-xylulose-5-phosphate synthase from bacterial and apicomplexan sources.

Current methods and applications in the study of 1-Deoxy-D-xylulose 5-phosphate synthase (DXPS).

Thiamine pyrophosphate-dependent enzymes in Toxoplasma gondii and functional significance of an apicoplast-localized pyruvate dehydrogenase.

Biochemical and cryo-EM studies of the pyruvate dehydrogenase complex from native cell extracts.

Synthesis of phosphonate and phosphinate analogs of 2-oxo acids for site-specific inhibition of thiamine-diphosphate-dependent dehydrogenases of 2-oxo acids in vivo.

Use of dihydroxyacetone synthase for the assimilation of methanol in E. coli.

Apoptosis-inducing potential of the hexane fraction of Cassia fistula L. against MCF-7 cells via apoptosis signaling pathways.

A novel 1,3-diazetidine-2-thione derivative with antibacterial and immunomodulatory activity against Proteus mirabilis: in vitro, in vivo, ADMET, docking, and molecular dynamics evaluation.

DancE: A DNA-Activated Bacterial cGAS-like Enzyme in Antiphage Immune Defense.

Reversible, Orally Bioavailable Small-Molecule Inhibitors Occupy the Substrate Tunnel of the Thioesterase Domain of Fatty Acid Synthase.

Peptides derived from TsAP-2 exhibit potential antifungal activity against Candida species and promote non-infected wound healing both in vitro and in vivo.

Dysoverines G-K from the rhizome of Dysosma tonkinense and their cytotoxic activity.

Related Experiment Videos

Inhibitors of gamma-aminobutyric acid transport as experimental tools and therapeutic agents

Related Concept Videos

Related Articles