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Hyalinizing spindle cell tumors with giant rosette-like structures

M Ludvíková1, M Michal, M Zámecník

  • 1Department of Pathology, Medical Faculty, Charles University, Pilsen, Czech Republic.

Pathology, Research and Practice
|October 21, 1998
PubMed
Summary

Two cases of hyalinizing spindle cell tumors with giant rosettes were identified in the pararectal space and wrist. These tumors showed unique collagen core rosettes and specific cellular markers, aiding in diagnosis.

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Area of Science:

  • Pathology
  • Oncology
  • Soft Tissue Tumors

Background:

  • Hyalinizing spindle cell tumors are rare neoplasms.
  • Giant rosettes are an unusual morphologic feature in soft tissue tumors.

Observation:

  • Two distinct cases of hyalinizing spindle cell tumors with giant rosettes were observed.
  • Tumors presented in the pararectal space and soft tissues of the wrist.
  • Microscopic examination revealed varied morphology including fibromatosis-like areas.

Findings:

  • The hallmark feature was the presence of giant rosettes with collagen cores.
  • Tumor cells showed diffuse immunoreactivity for lysozyme, CD-68, factor XIII, and vimentin.
  • Absence of reactivity for smooth muscle actin, desmin, and S-100 protein was noted.

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Implications:

  • This report expands the understanding of hyalinizing spindle cell tumor morphology.
  • Immunohistochemical findings provide diagnostic clues for these rare tumors.
  • Recognition of giant rosettes is crucial for accurate classification and diagnosis.