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Cefpodoxime pharmacokinetics in children: effect of food

G L Kearns1, S M Abdel-Rahman, R F Jacobs

  • 1Section of Pediatric Clinical Pharmacology and Experimental Therapeutics, The Children's Mercy Hospital, Kansas City, MO 64108, USA. gkearns@cmh.edu

The Pediatric Infectious Disease Journal
|October 21, 1998
PubMed

Insights

Food intake affects cefpodoxime absorption rate, not extent, in children. Cefpodoxime proxetil oral suspension can be given with or without meals for treating pediatric infections.

Area of Science:

  • Pharmacology
  • Pediatric Medicine
  • Infectious Diseases

Background:

  • Cefpodoxime is a third-generation cephalosporin antibiotic for pediatric upper respiratory tract infections.
  • This study investigated cefpodoxime proxetil oral suspension disposition in children.

Purpose of the Study:

  • To characterize the pharmacokinetic disposition of cefpodoxime proxetil oral suspension in children.
  • To compare drug absorption under fed versus fasted conditions.

Main Methods:

  • A randomized two-way crossover study involving 17 children (5 months to 12 years).
  • Single 10 mg/kg dose administered under fed and fasted states.
  • Plasma concentrations quantified via HPLC; pharmacokinetic parameters determined using nonlinear regression.

Main Results:

  • Cefpodoxime disposition modeled by a one-compartment open model.
  • No significant differences in AUC, Cmax, or Ke between fed and fasted states.
  • Tmax was prolonged and Ka was reduced under fed conditions, indicating slower absorption.

Conclusions:

  • Food administration impacts the rate, but not the extent, of cefpodoxime absorption.
  • Cefpodoxime proxetil oral suspension is suitable for pediatric administration regardless of meal status.
Abstract

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