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Updated: Aug 26, 2026

Characterization of G Protein-coupled Receptors by a Fluorescence-based Calcium Mobilization Assay
Published on: July 28, 2014
Genetic analysis of mammalian G-protein signalling
1Institut für Pharmakologie, Freie Universität Berlin, Germany.
Abstract:
Heterotrimeric G-proteins are important signalling proteins which function in all cells of the mammalian organism. Inactivating mutations in a variety of G-protein alpha-subunit genes in mice resulted in mostly unexpected phenotypes and have provided interesting new insight into their biological roles. Whereas the inactivation of some G alpha genes led to mild phenotypes suggesting the presence of redundant or compensatory mechanisms, other G-proteins appear to play highly specific biological or developmental roles. The purpose of this review is to summarize the current knowledge about G-protein functions based on gene-inactivation studies.
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