Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Increasing complexity of Ras signaling

S L Campbell1, R Khosravi-Far, K L Rossman

  • 1Department of Biochemistry and Biophysics, MIT, Cambridge, Massachusetts 02139, USA.

Oncogene
|October 21, 1998
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Understanding dropout during psychological treatment for gambling: A scoping review.

Clinical psychology review·2025
Same author

Microbial community changes in a female rat model of Rett syndrome.

Progress in neuro-psychopharmacology & biological psychiatry·2021
Same author

Comprehensive analysis utilizing flow cytometry and immunohistochemistry reveals inflammatory changes in local endometrial and systemic dendritic cell populations in endometriosis.

Human reproduction (Oxford, England)·2020
Same author

Emergence of multi-body interactions in a fermionic lattice clock.

Nature·2018
Same author

A Fermi-degenerate three-dimensional optical lattice clock.

Science (New York, N.Y.)·2017
Same author

Experimental warming and antecedent fire alter leaf element composition and increase soil C:N ratio in sub-alpine open heathland.

The Science of the total environment·2017

Mutated Ras proteins drive cancer by disrupting growth signaling pathways. Early linear models of Ras signal transduction have evolved to reveal a complex network with cross-talk and feedback loops.

Area of Science:

  • Molecular Biology
  • Cell Signaling
  • Oncology

Background:

  • Ras genes are implicated in cancer due to their role in promoting cell growth.
  • Mutated Ras proteins are found in numerous human cancers, suggesting a link to aberrant growth signaling.
  • Early research established a linear pathway for Ras signal transduction involving receptor tyrosine kinases and mitogen-activated protein kinases (MAPKs).

Purpose of the Study:

  • To review the current understanding of Ras signal transduction.
  • To highlight the complexities beyond the initial linear pathway model.
  • To emphasize the diverse signaling networks and effector interactions involving Ras and its subfamily proteins.

Main Methods:

  • Review of genetic analyses in model organisms (Drosophila, S. cerevisiae, C. elegans).

Related Experiment Videos

  • Biochemical and biological studies in mammalian cells.
  • Integration of experimental observations to define signaling cascades.

    • Main Results:

    • Ras functions as a crucial relay switch in signal transduction, connecting cell surface receptors to nuclear transcription factors via MAPKs.
    • The initial linear pathway model, while significant, represents only a small part of a complex signaling circuitry.
    • Ras signaling involves intricate networks with cross-talk, feedback loops, branch points, and multi-component complexes.

    Conclusions:

    • The understanding of Ras signal transduction has moved from a simple linear cascade to a complex circuitry.
    • Ras and Ras-subfamily proteins interact with multiple effectors, mediating diverse signaling pathways.
    • Aberrant Ras signaling contributes to malignant growth properties in cancer cells through complex regulatory mechanisms.