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A Protocol for Computer-Based Protein Structure and Function Prediction
16:41

A Protocol for Computer-Based Protein Structure and Function Prediction

Published on: November 3, 2011

From Src Homology domains to other signaling modules: proposal of the 'protein recognition code'

M Sudol1

  • 1The Department of Biochemistry, Mount Sinai School of Medicine, New York, NY 10029, USA.

Oncogene
|October 21, 1998
PubMed

Insights

Scientists propose a

Area of Science:

  • Molecular Biology
  • Cellular Signaling
  • Genomics

Background:

  • Oncogene research has significantly advanced cellular signaling understanding.
  • Protein modules, like Src Homology domains, are key to signal transduction.
  • Intracellular modules mediate crucial protein-protein interactions in various cellular processes.

Purpose of the Study:

  • To introduce the concept of a 'protein recognition code'.
  • To propose a finite set of rules governing module-mediated protein interactions.
  • To draw parallels between the genetic code and protein interactions.

Main Methods:

  • Characterization of well-known intracellular modules (e.g., SH2, SH3, PH, PTB, EH, PDZ, EVH1, WW domains).
  • Analysis of the modular nature, universal function, and interaction specificities of these domains.
  • Comparative analysis with the universal genetic code.

Main Results:

  • Identified several well-characterized intracellular modules involved in diverse cellular functions.
  • Highlighted the universality, widespread occurrence, and specific/degenerate interactions of these modules.
  • Established the foundation for the 'protein recognition code' concept.

Conclusions:

  • The modular nature of protein domains suggests an underlying code for interactions.
  • A finite set of rules likely governs protein-protein interactions mediated by modules.
  • Emerging rules of this 'protein recognition code' are being identified.

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