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[Bleeding in chronic refractory peptic ulcer]
T Nakamura1, K Yakabi, S Kurosawa
13rd Department of Medicine, Teikyo University School of Medicine, Ichihara Hospital.
Nihon Rinsho. Japanese Journal of Clinical Medicine
|October 22, 1998
Summary
Refractory ulcers cause significant bleeding complications, affecting over 10% of chronic ulcer cases. Understanding risk factors like age, NSAID use, and H. pylori infection is crucial for predicting and managing this serious clinical problem.
Area of Science:
- Gastroenterology
- Clinical Medicine
Background:
- Refractory and easily-relapsing ulcers represent a substantial clinical challenge, accounting for approximately 40% of all chronic ulcer cases.
- Bleeding is a significant complication associated with these ulcers, with reported rates exceeding 10%.
Purpose of the Study:
- To review the clinical problems associated with bleeding in refractory ulcers.
- To discuss the relationship between ulcer bleeding and various risk factors.
Main Methods:
- Literature review focusing on clinical problems of bleeding in refractory ulcers.
- Analysis of the incidence of refractory ulcers and their bleeding rates.
- Discussion of risk factors including age, NSAID use, and Helicobacter pylori infection.
Main Results:
- Refractory and easily-relapsing ulcers constitute about 40% of chronic ulcers.
- The bleeding rate in these ulcers is estimated to be over 10%.
Conclusions:
- Predicting ulcer bleeding remains difficult, highlighting the importance of considering associated risk factors.
- Understanding the interplay of age, NSAID use, and H. pylori infection is critical for managing refractory ulcer bleeding.