Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Adult brainstem gliomas

J C Landolfi1, H T Thaler, L M DeAngelis

  • 1Department of Neurology, Memorial Sloan-Kettering Cancer Center, New York, NY 10021, USA.

Neurology
|October 22, 1998
PubMed
Summary

Adult brainstem gliomas show longer survival than in children, suggesting a less aggressive disease. Some patients may be initially managed with observation alone.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

A pilot study of neuropsychological functions, APOE and amyloid imaging in patients with gliomas.

Journal of neuro-oncology·2017
Same author

OC-02 - Risk of arterial thromboembolism in patients with breast cancer.

Thrombosis research·2016
Same author

Prospective assessment of white matter integrity in adult stem cell transplant recipients.

Brain imaging and behavior·2015
Same author

Multimodality imaging of primary CNS lymphoma in immunocompetent patients.

The British journal of radiology·2014
Same author

A prospective evaluation of changes in brain structure and cognitive functions in adult stem cell transplant recipients.

Brain imaging and behavior·2013
Same author

Modern concepts in the biology, diagnosis, differential diagnosis and treatment of primary central nervous system lymphoma.

Leukemia·2011

Area of Science:

  • Neuro-oncology
  • Clinical Neurology

Background:

  • Brainstem glioma predominantly affects children with poor prognosis (9-12 months median survival).
  • Prognosis and survival data for adult brainstem gliomas remain imprecise.

Purpose of the Study:

  • To determine prognostic factors for adult brainstem gliomas.
  • To evaluate survival rates in adult patients diagnosed with brainstem gliomas.

Main Methods:

  • Retrospective analysis of patients over 16 years old diagnosed between 1989-1997.
  • Assessment of factors including age, gender, symptoms, tumor characteristics, and treatment on survival.

Main Results:

  • Median survival for adults was 54 months, with a 5-year survival rate of 45%.
  • Higher Karnofsky performance status showed a trend towards longer survival, but not statistically significant.
  • Other evaluated factors did not significantly impact survival.

Conclusions:

  • Adult brainstem gliomas appear to have a better prognosis and may be less aggressive than in pediatric cases.
  • Observation alone may be a suitable initial management strategy for select adult patients with specific tumor characteristics or long symptom duration.

Related Experiment Videos