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Salt-dependent haemagglutinating measles virus in S.S.P.E
The Journal of General Virology
|October 1, 1976
Summary
Two strains of Subacute Sclerosing Panencephalitis (SSPE) virus exhibit both hemagglutinin and salt-dependent hemagglutinin properties. These traits correlate with distinct plaque morphologies, suggesting salt-dependent strains may exist in early SSPE isolates.
Area of Science:
- Virology
- Microbiology
Background:
- Subacute Sclerosing Panencephalitis (SSPE) is a severe neurological complication of measles virus infection.
- Understanding the properties of SSPE virus strains is crucial for disease research.
Purpose of the Study:
- To investigate the hemagglutinin properties of SSPE virus strains.
- To determine the association between hemagglutinin characteristics and viral plaque morphology.
Main Methods:
- Analysis of hemagglutinin activity in two SSPE virus strains.
- Observation and characterization of distinct plaque forms associated with each strain.
Main Results:
- Both SSPE virus strains demonstrated hemagglutinin and salt-dependent hemagglutinin activity.
- Specific plaque morphologies were observed and linked to the hemagglutinin properties within each strain.
Conclusions:
- The presence of salt-dependent hemagglutinin in wild-type measles virus implies its potential presence in early SSPE isolates.
- Distinct plaque forms are associated with specific hemagglutinin properties in SSPE virus strains.