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Acadesine increases blood flow in the collateralized heart during exercise
Y Ishibashi1, B B Quebbeman, D J Duncker
1Department of Medicine, University of Minnesota Medical School, Minneapolis 55455, USA.
Journal of Cardiovascular Pharmacology
|October 22, 1998
Summary
Acadesine improved blood flow in collateral-dependent heart regions during exercise in dogs by reducing resistance. This adenosine-regulating agent enhanced myocardial blood flow in collateralized hearts but not in normal ones.
Area of Science:
- Cardiovascular Physiology
- Pharmacology
- Myocardial Perfusion
Background:
- Acadesine (adenosine-regulating agent) increases coronary flow and protects ischemic myocardium.
- Its effect on coronary collateral flow during exercise is not well-established.
Purpose of the Study:
- To investigate acadesine's impact on myocardial blood flow during exercise in dogs with and without coronary collateral vessels.
Main Methods:
- Treadmill exercise test in normal dogs and dogs with induced coronary collateral vessels.
- Intravenous administration of acadesine (100 micromol/min).
- Measurement of myocardial blood flow in collateral-dependent and normal zones.
Main Results:
- Acadesine increased blood flow in collateral-dependent regions by 24% during exercise in collateralized dogs.
- This increase was due to reduced transcollateral and small-vessel resistance.
- Acadesine enhanced blood flow in both collateral and normal zones in collateralized dogs, but had no effect in normal dogs.
Conclusions:
- Acadesine improves exercise-induced myocardial blood flow in collateralized hearts.
- Adenosine metabolism appears altered in both collateral-dependent and normal regions of occluded hearts.