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Pseudomyxoma peritonei
1Department of General Surgery, St James's University Hospital, Leeds, UK.
The British Journal of Surgery
|October 22, 1998
Summary
Pseudomyxoma peritonei is a neoplastic condition, often originating from the appendix. Treatment involves extensive surgery and potentially adjuvant therapies, though recurrence is common.
Area of Science:
- Oncology
- Gastroenterology
- Pathology
Background:
- Pseudomyxoma peritonei involves gelatinous fluid and mucinous implants on peritoneal surfaces.
- Its pathological origin and optimal treatment remain subjects of debate.
Purpose of the Study:
- To review the literature on pseudomyxoma peritonei.
- To discuss the neoplastic origin, treatment strategies, and prognosis of this rare condition.
Main Methods:
- An unrestricted Medline search was conducted for pseudomyxoma peritonei literature from 1986 to 1997.
Main Results:
- Evidence suggests pseudomyxoma peritonei is neoplastic, often arising from appendiceal adenoma or adenocarcinoma.
- Pathological findings range from benign mucocele to advanced carcinoma.
- Surgical debulking is generally recommended, often requiring multidisciplinary teams and adjuvant therapies.
Conclusions:
- Pseudomyxoma peritonei is a spectrum of neoplastic disease, typically appendiceal in origin.
- Treatment requires planned surgical debulking, possibly with intraperitoneal chemotherapy or radioisotope therapy.
- Recurrence is frequent, with 5-year survival rates varying from 53-75% based on disease subgroup.