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Pseudomyxoma peritonei

F L Hinson1, N S Ambrose

  • 1Department of General Surgery, St James's University Hospital, Leeds, UK.

The British Journal of Surgery
|October 22, 1998
PubMed
Summary
This summary is machine-generated.

Pseudomyxoma peritonei is a neoplastic condition, often originating from the appendix. Treatment involves extensive surgery and potentially adjuvant therapies, though recurrence is common.

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Area of Science:

  • Oncology
  • Gastroenterology
  • Pathology

Background:

  • Pseudomyxoma peritonei involves gelatinous fluid and mucinous implants on peritoneal surfaces.
  • Its pathological origin and optimal treatment remain subjects of debate.

Purpose of the Study:

  • To review the literature on pseudomyxoma peritonei.
  • To discuss the neoplastic origin, treatment strategies, and prognosis of this rare condition.

Main Methods:

  • An unrestricted Medline search was conducted for pseudomyxoma peritonei literature from 1986 to 1997.

Main Results:

  • Evidence suggests pseudomyxoma peritonei is neoplastic, often arising from appendiceal adenoma or adenocarcinoma.
  • Pathological findings range from benign mucocele to advanced carcinoma.

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  • Surgical debulking is generally recommended, often requiring multidisciplinary teams and adjuvant therapies.

    • Conclusions:

    • Pseudomyxoma peritonei is a spectrum of neoplastic disease, typically appendiceal in origin.
    • Treatment requires planned surgical debulking, possibly with intraperitoneal chemotherapy or radioisotope therapy.
    • Recurrence is frequent, with 5-year survival rates varying from 53-75% based on disease subgroup.