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Related Experiment Videos

Gamma knife radiosurgery for hemangioblastomas

L Pan1, E M Wang, B J Wang

  • 1Department of Neurosurgery, Hua Shan Hospital, Shanghai Gamma Knife Hospital, Shanghai Medical University, Shanghai.

Stereotactic and Functional Neurosurgery
|October 23, 1998
PubMed
Summary
This summary is machine-generated.

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Gamma Knife radiosurgery (GKR) effectively treats solid cerebral hemangioblastomas (HABs), particularly in critical brain areas. However, GKR is less reliable for managing HAB cysts, which may require further intervention.

Area of Science:

  • Neurosurgery
  • Radiation Oncology
  • Oncology

Background:

  • Cerebral hemangioblastomas (HABs) are rare tumors.
  • Surgical resection is a primary treatment, but recurrence or residual disease necessitates alternative therapies.
  • Gamma Knife radiosurgery (GKR) offers a non-invasive treatment option.

Purpose of the Study:

  • To evaluate the efficacy and outcomes of Gamma Knife radiosurgery (GKR) for treating cerebral hemangioblastomas (HABs).
  • To assess the impact of GKR on solid tumor components versus cystic components of HABs.
  • To analyze histopathological changes following GKR and subsequent surgery.

Main Methods:

  • Retrospective analysis of 13 patients with cerebral hemangioblastomas (HABs) treated with Gamma Knife radiosurgery (GKR).

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  • Inclusion of patients with single or multiple lesions, including those with recurrent/residual disease and von Hippel-Lindau (VHL) disease.
  • Assessment of clinical status, tumor volume changes, and histopathological findings after GKR, with some cases undergoing post-GKR surgery.

    • Main Results:

    • 5 out of 13 patients showed symptom improvement and tumor volume reduction.
    • 4 patients remained clinically stable with unchanged tumor volume.
    • 3 patients experienced clinical deterioration, attributed to cyst expansion or radiation effects, with 2 requiring subsequent surgery for improvement.
    • Histopathology revealed vessel thickening, occlusion, and tumor cell loss, varying with time post-GKR.

    Conclusions:

    • Gamma Knife radiosurgery (GKR) demonstrates effectiveness in treating solid components of cerebral hemangioblastomas (HABs), especially in eloquent locations.
    • GKR is less reliable for controlling HAB cysts, which may necessitate further surgical intervention.
    • GKR may reduce vascularity, potentially making subsequent surgeries less hazardous.