Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Transmissible gastroenteritis coronavirus carrier sow

R D Woods1, R D Wesley

  • 1Virology Swine Research Unit, USDA, Ames, Iowa 50010, USA.

Advances in Experimental Medicine and Biology
|October 23, 1998
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Shadowing the actions of a predator: backlit fluorescent microscopy reveals synchronous nonbinary septation of predatory Bdellovibrio inside prey and exit through discrete bdelloplast pores.

Journal of bacteriology·2010
Same author

Genomic characterization of virulent, attenuated, and revertant passages of a North American porcine reproductive and respiratory syndrome virus strain.

Virology·2004
Same author

Bovine viral diarrhea virus isolated from fetal calf serum enhances pathogenicity of attenuated transmissible gastroenteritis virus in neonatal pigs.

Journal of veterinary diagnostic investigation : official publication of the American Association of Veterinary Laboratory Diagnosticians, Inc·2003
Same author

Recombinant adenovirus encoding the HA gene from swine H3N2 influenza virus partially protects mice from challenge with heterologous virus: A/HK/1/68 (H3N2).

Archives of virology·2002
Same author

Partial passive protection with two monoclonal antibodies and frequency of feeding of hyperimmune anti-transmissible gastroenteritis virus (TGEV) serum for protection of three-day-old piglets from a TGEV challenge infection.

Journal of veterinary diagnostic investigation : official publication of the American Association of Veterinary Laboratory Diagnosticians, Inc·2001
Same author

Efficacy of a transmissible gastroenteritis coronavirus with an altered ORF-3 gene.

Canadian journal of veterinary research = Revue canadienne de recherche veterinaire·2001

A sow infected with transmissible gastroenteritis virus (TGEV) shed the virulent virus for 18 months, acting as a long-term reservoir. This demonstrates a potential risk for disease transmission in swine populations.

Area of Science:

  • Veterinary Virology
  • Swine Infectious Diseases
  • Epidemiology

Background:

  • Transmissible gastroenteritis virus (TGEV) causes significant economic losses in swine production.
  • Understanding TGEV shedding dynamics is crucial for controlling disease outbreaks.

Purpose of the Study:

  • To investigate the duration and characteristics of virulent TGEV shedding in an experimentally infected sow.
  • To determine if a persistently infected sow can serve as a long-term reservoir for virulent TGEV.

Main Methods:

  • A sow was experimentally infected with virulent TGEV.
  • Rectal swabs were collected regularly for virus isolation and titration over 18 months.
  • Tissues (spleen, lymph nodes, liver) were analyzed for TGEV presence post-mortem.

Related Experiment Videos

  • Piglets were inoculated with isolated virus to confirm virulence.

    • Main Results:

    • Virulent TGEV was shed by the sow for 18 months post-exposure.
    • Virus shedding occurred at irregular intervals, with durations of 1-5 consecutive days.
    • Titer of shed virus ranged from <1x10(2) to 7.2x10(3) pfu/ml.
    • Virulent TGEV was re-isolated from the sow's spleen, mesenteric lymph nodes, and liver 544 days post-exposure.

    Conclusions:

    • An apparently healthy sow can act as a persistent reservoir for virulent TGEV.
    • Extended shedding of virulent TGEV poses a continuous risk for disease transmission in swine herds.
    • This highlights the importance of biosecurity and surveillance for TGEV in breeding sows.