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Allosteric modulation of neuronal nicotinic acetylcholine receptors
1Department of Physiology, Medical Faculty, Geneva, Switzerland.
Journal of Physiology, Paris
|October 23, 1998
Abstract:
The structure-function relationship of the neuronal nicotinic acetylcholine receptor is examined in the light of the allosteric concepts. Effects of site-directed mutagenesis as well as those caused by allosteric effector of the physiological and pharmacological receptor properties are discussed.