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Regulation of the cholinergic gene locus
1Department of Biochemistry, University of Kentucky, Lexington 40536-0084, USA.
Journal of Physiology, Paris
|October 23, 1998
Abstract:
DNase I hypersensitive site mapping of the human cholinergic gene locus has been used to detect cholinergic specific potential regulatory sites. Analysis of mutant PC12 cell lines provides evidence that protein kinase A II is required and coordinately regulates basal expression of both the ChAT and VAChT genes.