Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Clinical validation of a new olfactory test

B Kremer1, L Klimek, R Mösges

  • 1Department of Otorhinolaryngology, Head and Neck Surgery, University Hospital of Maastricht, The Netherlands.

European Archives of Oto-Rhino-Laryngology : Official Journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : Affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery
|October 23, 1998
PubMed
Summary

A novel nasal spray method for clinical olfactometry offers a standardized and highly accurate way to assess smell function. This easy-to-use screening test demonstrates excellent sensitivity and specificity for detecting olfactory disorders.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

No Evidence of Microsatellite Instability in Head and Neck Squamous Cell Carcinoma of Non-Smokers and Non-Drinkers.

Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology·2026
Same author

Frequent PD-L1 expression in oral squamous cell carcinoma of non-smokers and non-drinkers, and association of tumor infiltrating lymphocytes with favorable prognosis.

Translational oncology·2025
Same author

The effects of surface electrical stimulation plus voice therapy in Parkinson's disease.

The Journal of laryngology and otology·2022
Same author

Swallowing Assessment in Parkinson's Disease: Patient and Investigator Reported Outcome Measures are not Aligned.

Dysphagia·2020
Same author

[Histamine receptors in chronic inflammatory diseases of the nose and paranasal sinuses].

HNO·2019
Same author

Guidance to 2018 good practice: ARIA digitally-enabled, integrated, person-centred care for rhinitis and asthma.

Clinical and translational allergy·2019

Area of Science:

  • Otorhinolaryngology
  • Neuroscience
  • Sensory Science

Background:

  • Clinical olfactometry is crucial for diagnosing smell dysfunction.
  • Traditional methods can be time-consuming and lack standardization.
  • A need exists for a more accessible and reliable smell assessment tool.

Purpose of the Study:

  • To introduce and validate a new nasal spray-based approach for clinical olfactometry.
  • To compare the efficacy of the nasal spray method with traditional olfactory testing.
  • To establish the diagnostic accuracy of the spray test for olfactory disorders.

Main Methods:

  • A standardized nasal spray device delivering 40-micron aerosols was developed.
  • A 6x6 matrix with verbal associative clues was used for substance identification.

Related Experiment Videos

  • Validation involved comparing spray administration with bottle sniffing in normosmic subjects.
  • Reproducibility was assessed with reduced substance sets in normosmic and hyposmic individuals.
  • Final validation included patients with hyposmia and normosmic controls.

    • Main Results:

    • The nasal spray test achieved high global identification rates (98.4%) compared to bottle sniffing.
    • Six substances were selected for optimal reproducibility across subject groups.
    • The spray test demonstrated high sensitivity (88%) and perfect specificity (100%) in identifying olfactory dysfunction.
    • Results were reproducible regardless of the cause of hyposmia.

    Conclusions:

    • The nasal spray olfactometry method is a practical and effective tool for clinical smell assessment.
    • It serves as a reliable screening test for detecting hyposmia.
    • This approach offers a standardized, sensitive, and specific alternative to traditional olfactometry.