Pharmacokinetics and oral bioavailability of glycopyrrolate in children
P Rautakorpi1, T Manner, T Ali-Melkkilä
1Department of Anaesthesiology, Turku University Hospital, Finland.
Abstract:
Based on plasma levels determined with a radioreceptor assay and following a single oral (50 micrograms/kg) and intravenous (5 micrograms/kg) administration of glycopyrrolate in six healthy children operated twice during a several weeks period, a negligible and variable oral bioavailability was found (3.3; 1.3-13.3%) (median;range). No significant changes in heart rate after oral or intravenous administration of the drug could be seen. Oral glycopyrrolate appears to have no place in paediatric premedication.
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