Drosophila melanogaster as a model system for the study of the function of calcium/calmodulin-dependent protein...

Drosophila melanogaster has been used as a biological model system for almost a century. In the last several decades, Drosophila has been used as a system to probe the molecular basis of behavior and discoveries in the fly have been at the forefront of the elucidation of important basic mechanisms. This review will outline the variety of approaches that make Drosophila an excellent model system with which to study the function of the enzyme calcium/calmodulin-dependent protein kinase II (CaMKII) in synaptic plasticity. CaMKII has a well documented role in behavior and synaptic plasticity in both vertebrates and invertebrates. The behavioral and genetic richness of Drosophila allow for a multi-level approach to understanding the physiological roles of this enzyme's function.