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Bioavailability of rifampicin, isoniazid and pyrazinamide from fixed-dose combination capsules
Z Zwolska1, H Niemirowska-Mikulska, E Augustynowicz-Kopec
1National Research Institute of Tuberculosis and Lung Diseases, Warsaw, Poland.
Setting:
The absorption of rifampicin, isoniazid and pyrazinamide was tested after administration of each drug in free combinations and in a fixed-dose combination of the three drugs, known as Trifazid.
Objective:
To examine the relative bioavailability of rifampicin, isoniazid and pyrazinamide after oral administration of the drugs given alone in comparison to that of the same drugs after administration of Trifazid.
Design:
An open, randomized, cross-over study comprising 16 healthy volunteers.
Results:
The pattern of absorption, plasma concentrations and pharmacokinetic parameters were very similar after administration of the drugs in free and fixed combinations.
Conclusion:
The triple combination of antituberculosis drugs could replace the separate drugs in the treatment of tuberculosis.