Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Experimental evaluation of three single-particle dissolution models

P V Pedersen, K F Brown

    Journal of Pharmaceutical Sciences
    |October 1, 1976
    PubMed
    Summary
    This summary is machine-generated.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Nucleotide supplementation: a randomised double-blind placebo controlled trial of IntestAidIB in people with Irritable Bowel Syndrome [ISRCTN67764449].

    Nutrition journal·2006
    Same author

    Validation of methods to study the distribution and protein binding of tacrolimus in human blood.

    Journal of pharmacological and toxicological methods·2002
    Same author

    Influence of respiratory spacer devices on aerodynamic particle size distribution and fine particle mass of beclomethasone from metered-dose inhalers.

    Journal of aerosol medicine : the official journal of the International Society for Aerosols in Medicine·2002
    Same author

    High-performance liquid chromatographic analysis of mometasone furoate and its degradation products: application to in vitro degradation studies.

    Journal of pharmaceutical and biomedical analysis·2001
    Same author

    In-vitro characterisation of metered dose inhaler versus dry powder inhaler glucocorticoid products: influence of inspiratory flow rates.

    Journal of pharmacy & pharmaceutical sciences : a publication of the Canadian Society for Pharmaceutical Sciences, Societe canadienne des sciences pharmaceutiques·2001
    Same author

    Metabolism kinetics of beclomethasone propionate esters in human lung homogenates.

    Pharmaceutical research·2000

    This study introduces a novel method for analyzing drug dissolution kinetics in multiparticulate systems. The approach accurately models particle size and shape effects on drug release rates.

    Area of Science:

    • Pharmaceutical Sciences
    • Physical Chemistry
    • Materials Science

    Background:

    • Understanding drug dissolution is critical for predicting in vivo performance.
    • Multiparticulate systems present complex dissolution profiles due to particle heterogeneity.
    • Accurate kinetic modeling is essential for drug formulation development.

    Purpose of the Study:

    • To develop and validate a method for analyzing dissolution kinetics of multiparticulate systems.
    • To quantitatively evaluate single-particle dissolution models for complex systems.
    • To mathematically explain multiparticulate kinetics considering particle characteristics.

    Main Methods:

    • Utilized a flow-through dissolution apparatus with a dissolution cell for the 60-85-mesh fraction.

    Related Experiment Videos

  • Employed a time-scaling approach to compare experimental data with theoretical calculations.
  • Modeled nonspherical particles as a hypothetical system of log-normally distributed spheres for calculations.

    • Main Results:

    • Identified the best-fitting single-particle dissolution model for the experimental data.
    • Successfully explained multiparticulate dissolution kinetics mathematically.
    • Calculated the intrinsic dissolution profile, accounting for particle size distribution and shape.

    Conclusions:

    • The developed method is suitable for kinetic analysis of multiparticulate systems.
    • The time-scaling approach combined with hypothetical spherical particle modeling provides quantitative insights.
    • This approach enables accurate prediction of drug release profiles considering particle morphology.