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Cutaneous angiomyolipoma: report of two cases with emphasis on HMB-45 utility
N Büyükbabani1, S Tetikkurt, A S Oztürk
1Department of Pathology, Istanbul University, Istanbul School of Medicine, Turkey.
Background:
Angiomyolipomas are tumors composed of adipose tissue, blood vessels and smooth muscle. Although renal angiomyolipomas are well known, cutaneous tumors have been described only recently. HMB-45 reactivity, reported for renal angiomyolipomas, has been suggested as a useful tool in differential diagnosis.
Objective:
Two cases of cutaneous angiomyolipoma are described and investigated for HMB-45 reactivity.
Methods:
Conventional histochemical and immunohistochemical methods were used.
Results:
Immunohistochemical analysis showed no reactivity for HMB-45 antibody.
Conclusion:
We conclude that, unlike renal angiomyolipomas, HMB-45 reactivity is not helpful in differentiating cutaneous angiomyolipomas.