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Updated: Jul 23, 2026
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Hi-C: A Method to Study the Three-dimensional Architecture of Genomes.
Published on: May 6, 2010
New goals for the U.S. Human Genome Project: 1998-2003
F S Collins1, A Patrinos, E Jordan
1National Human Genome Research Institute, National Institutes of Health, Bethesda, MD 20892, USA. fc23a@nih.gov
Science (New York, N.Y.)
|October 23, 1998
Summary
The Human Genome Project is accelerating its timeline, aiming for a complete human DNA sequence by 2003. This ambitious plan includes a working draft by 2001 and advances in sequencing technology and genomics research.
Area of Science:
- Genomics
- Molecular Biology
- Bioinformatics
Background:
- The Human Genome Project (HGP) successfully met its 1993-1998 objectives.
- A revised strategic plan (1998-2003) has been established to guide future HGP endeavors.
Purpose of the Study:
- To outline the HGP's updated goals, emphasizing the completion of the human DNA sequence.
- To detail advancements in sequencing technology, functional genomics, and comparative genomics.
Main Methods:
- Accelerated human DNA sequencing to produce a working draft by 2001 and full sequence by 2003.
- Development of advanced sequencing technologies and functional genomics tools.
- Comparative genomics studies including *Caenorhabditis elegans*, *Drosophila melanogaster*, and the mouse genome.
Main Results:
- Completion of all major goals for the 1993-1998 HGP plan.
- Establishment of an accelerated schedule for human genome sequencing.
- Initiation of comprehensive studies on human genome sequence variation and functional genomics.
Conclusions:
- The Human Genome Project is on track for an earlier completion of the human DNA sequence.
- The project will yield significant advancements in sequencing technology, functional genomics, and understanding genome variation.
- Broader impacts include ethical, legal, and social implications studies, bioinformatics development, and scientist training.
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