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Related Experiment Videos

A streptococcal adhesion system for salivary pellicle and platelets

K Gong1, T Ouyang, M C Herzberg

  • 1Department of Preventive Sciences, School of Dentistry, University of Minnesota, Minneapolis, Minnesota 55455, USA.

Infection and Immunity
|October 24, 1998
PubMed
Summary

Streptococcus sanguis uses a specific adhesin to bind saliva-coated hydroxylapatite and platelets. This binding system is common in viridans group streptococci, though some strains use alternative adhesins for saliva-coated hydroxylapatite binding.

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Area of Science:

  • Microbiology
  • Bacterial Adhesion
  • Molecular Biology

Background:

  • Streptococcus sanguis possesses adhesins crucial for colonizing host surfaces.
  • A specific adhesin (identified by MAb 1.1) binds saliva-coated hydroxylapatite (sHA) and platelets.
  • The binding site for this adhesin was characterized using an anti-idiotypical MAb 2.1.

Purpose of the Study:

  • To investigate the prevalence of this specific adhesion system within the Streptococcus sanguis group and other viridans group streptococci.
  • To determine if strains binding to sHA and platelets share common adhesin and binding site epitopes.
  • To identify alternative adhesion mechanisms in strains lacking platelet-binding capabilities.

Main Methods:

  • Testing 42 strains from seven species of viridans group streptococci for binding to sHA and platelets.

Related Experiment Videos

  • Utilizing monoclonal antibodies (MAb 1.1 and MAb 2.1) to identify specific adhesin and binding site interactions.
  • Comparative analysis of adhesion properties among different strains.

    • Main Results:

    • Strains of Streptococcus sanguis that bind to both sHA and platelets utilize the same adhesin and binding site epitopes.
    • A subset of strains binds to sHA but not platelets, indicating the use of different adhesin specificities.
    • The MAb 1.1 and MAb 2.1 defined adhesion system is a common mechanism in the tested viridans group streptococci.

    Conclusions:

    • The characterized adhesin-binding system is a conserved mechanism among certain viridans group streptococci.
    • Streptococcus sanguis employs distinct adhesin strategies for binding sHA, depending on platelet interaction.
    • Understanding these adhesin specificities is vital for comprehending oral streptococcal colonization and pathogenesis.