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Photoaffinity study of the cellular interactions of ilimaquinone
1Eugene F. Merkert Chemistry Center, Boston College, Chestnut Hill, MA 02167-3860, USA.
Bioorganic & Medicinal Chemistry
|October 24, 1998
Abstract:
The marine sponge metabolite ilimaquinone (1) displays a broad range of biological activities. To better understand the effects of this natural product, a photoaffinity analogue was synthesized and used to probe the cellular interactions of ilimaquinone. Irradiation of photoaffinity probe 5 with liver cytosol in the presence and absence of excess competitive inhibitor 2 suggests that S-adenosylhomocysteinase is an important intracellular target of ilimaquinone.
