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Ca2+ signaling in T-lymphocytes

A H Guse1

  • 1University of Hamburg, Dept. of Enzyme Chemistry, Germany.

Critical Reviews in Immunology
|October 24, 1998
PubMed
Summary
This summary is machine-generated.

Calcium (Ca2+) signaling is crucial for T cell proliferation following antigen stimulation. This review covers key aspects of Ca2+ signaling, including second messengers, calcium entry, and oscillations in T lymphocytes.

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Area of Science:

  • Immunology
  • Cellular Biology
  • Molecular Signaling

Background:

  • Calcium (Ca2+) signaling is a fundamental process in T-lymphocyte activation.
  • Antigenic stimulation triggers early events in T-lymphocyte signal transduction.
  • The T cell receptor/CD3 complex plays a central role in initiating Ca2+ signaling.

Purpose of the Study:

  • To review the critical role of Ca2+ signaling in T cell proliferation.
  • To explore the mechanisms and mediators of Ca2+ mobilization upon T cell activation.
  • To discuss Ca2+ signaling induced by various stimuli beyond the T cell receptor.

Main Methods:

  • Literature review of studies on T cell calcium signaling.
  • Analysis of second messenger pathways, including inositol 1,4,5-trisphosphate and cyclic ADP-ribose.

Related Experiment Videos

  • Examination of calcium ion (Ca2+) entry mechanisms and oscillatory patterns.

    • Main Results:

    • Detailed review of the generation, metabolism, and function of Ca2+-mobilizing second messengers.
    • Explanation of the mechanisms governing Ca2+ entry into T cells.
    • Description of single-cell Ca2+ oscillations and their significance.

    Conclusions:

    • Ca2+ signaling is indispensable for T cell proliferation and immune response.
    • Multiple intracellular messengers and pathways contribute to T cell activation via Ca2+.
    • Ca2+ signaling in T cells can be modulated by diverse surface receptors and stimuli.